Lymphoid Organ Alterations Enhanced By Sub-lethal Doses Of Coronaviruses In Experimentally Induced Trypanosoma Cruzi Infection In Mice.

dc.creatorVerinaud, L
dc.creatorCamargo, I J
dc.creatorVassallo, J
dc.creatorSakurada, J K
dc.creatorRangel, H A
dc.date1999-Feb
dc.date2015-11-27T12:19:34Z
dc.date2015-11-27T12:19:34Z
dc.date.accessioned2018-03-29T00:53:26Z
dc.date.available2018-03-29T00:53:26Z
dc.identifierLaboratory Animal Science. v. 49, n. 1, p. 35-41, 1999-Feb.
dc.identifier0023-6764
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10090092
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194343
dc.identifier10090092
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294576
dc.descriptionThe effect of sub-lethal doses of coronaviruses on the course of disease in CBA mice experimentally infected with a mildly pathogenic strain of Trypanosoma cruzi was investigated. Mice were inoculated with either T. cruzi, 0.1 median lethal dose (LD50) of coronavirus (mouse hepatitis virus [MHV-3] or virus X), or both pathogens. Levels of parasitemia, mortality, and the extent of pathologic alterations in lymphoid organs were determined. Mice inoculated with T. cruzi had mild alterations in their lymphoid organs and survived infection. In contrast, mice inoculated with both pathogens died, and had significantly higher levels of parasitemia and profound alterations in lymphoid organs. These results indicate that the pathologic profile of T. cruzi infection can be profoundly altered by subclinical infection with coronaviruses.
dc.description49
dc.description35-41
dc.languageeng
dc.relationLaboratory Animal Science
dc.relationLab. Anim. Sci.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBone Marrow Cells
dc.subjectCell Count
dc.subjectChagas Disease
dc.subjectCoronavirus Infections
dc.subjectFemale
dc.subjectHematopoietic Stem Cells
dc.subjectLymph Nodes
dc.subjectLymphoid Tissue
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMice, Inbred Cba
dc.subjectOrgan Size
dc.subjectParasitemia
dc.subjectSpleen
dc.subjectThymus Gland
dc.subjectTrypanosoma Cruzi
dc.titleLymphoid Organ Alterations Enhanced By Sub-lethal Doses Of Coronaviruses In Experimentally Induced Trypanosoma Cruzi Infection In Mice.
dc.typeArtículos de revistas


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