Autonomous Proliferation And Bcl-2 Expression Involving Haematopoietic Cells In Patients With Myelodysplastic Syndrome.

dc.creatorBincoletto, C
dc.creatorSaad, S T
dc.creatorSoares da Silva, E
dc.creatorQueiroz, M L
dc.date1998-Sep
dc.date2015-11-27T12:19:22Z
dc.date2015-11-27T12:19:22Z
dc.date.accessioned2018-03-29T00:53:02Z
dc.date.available2018-03-29T00:53:02Z
dc.identifierBritish Journal Of Cancer. v. 78, n. 5, p. 621-4, 1998-Sep.
dc.identifier0007-0920
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9744502
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194238
dc.identifier9744502
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294471
dc.descriptionIn this work, we investigated the autonomous proliferation, bcl-2 expression and number of apoptotic cells in the bone marrow of patients with confirmed diagnosis of myelodysplastic syndromes (MDS). Normal bone marrow cells obtained from donors of the Clinical Hospital of this university were used as a control. The autonomous proliferation, evaluated by clonal culture without exogenous growth factor, and the number of apoptotic cells in bone marrow kept for 10 days in liquid cultures at 37 degrees C and 5% carbon dioxide, were significantly greater in MDS patients than in control subjects (P = 0.001, Wilcoxon). However, bcl-2 expression, measured by immunocytochemistry, was significantly lower in MDS patients than in normal individuals (P = 0.002, Wilcoxon). These results suggest that the high proliferation activity in MDS patients may be counteracted by the high level of medullar cell death, which might be related to the lower bcl-2 expression.
dc.description78
dc.description621-4
dc.languageeng
dc.relationBritish Journal Of Cancer
dc.relationBr. J. Cancer
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectApoptosis
dc.subjectCell Division
dc.subjectColony-forming Units Assay
dc.subjectHematopoietic Stem Cells
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMyelodysplastic Syndromes
dc.subjectProto-oncogene Proteins C-bcl-2
dc.titleAutonomous Proliferation And Bcl-2 Expression Involving Haematopoietic Cells In Patients With Myelodysplastic Syndrome.
dc.typeArtículos de revistas


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