Distribution Of Hla-drb1 Alleles In A Mixed Population With Insulin-dependent Diabetes Mellitus From The Southeast Of Brazil.

dc.creatorMarques, S B
dc.creatorVolpini, W
dc.creatorCaillat-Zucman, S
dc.creatorLieber, S R
dc.creatorPavin, E J
dc.creatorPersoli, L B
dc.date1998-Mar
dc.date2015-11-27T12:19:18Z
dc.date2015-11-27T12:19:18Z
dc.date.accessioned2018-03-29T00:52:54Z
dc.date.available2018-03-29T00:52:54Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 31, n. 3, p. 365-8, 1998-Mar.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9698783
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194209
dc.identifier9698783
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294442
dc.descriptionHLA class II genes are strongly associated with susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). The present study reports the HLA-DRB1 genotyping of 41 IDDM patients and 99 healthy subjects from the Southeast of Brazil (Campinas region). Both groups consisted of an ethnic mixture of Caucasian, African Negro and Amerindian origin. HLA-DRB1*03 and *04 alleles were found at significantly higher frequencies among IDDM patients compared to the controls (DRB1*03: 48.8% vs 18.2%, P < 0.005, RR = 4.27; DRB1*04: 43.9% vs 15.1%, P < 0.008, RR = 4.37) and were associated with a susceptibility to the disease. DRB1*03/*04 heterozygosity conferred a strong IDDM risk (RR = 5.44). In contrast, the HLA-DRB1*11 allele frequency was lower among IDDM patients (7.3% vs 26.3% in controls), but the difference was not significant. These data agree with those described for other populations and allow genetic characterization of IDDM in Brazil.
dc.description31
dc.description365-8
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAlleles
dc.subjectBrazil
dc.subjectDiabetes Mellitus, Type 1
dc.subjectDisease Susceptibility
dc.subjectElectron Transport Complex Iv
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetics, Population
dc.subjectGenome, Fungal
dc.subjectGenotype
dc.subjectHla-dr Antigens
dc.subjectHumans
dc.subjectMale
dc.subjectSaccharomyces Cerevisiae
dc.titleDistribution Of Hla-drb1 Alleles In A Mixed Population With Insulin-dependent Diabetes Mellitus From The Southeast Of Brazil.
dc.typeArtículos de revistas


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