Atypical Stromal Giant Cells Of Cervix Uteri--evidence Of Schwann Cell Origin.

dc.creatorMetze, K
dc.creatorAndrade, L A
dc.date1991-Dec
dc.date2015-11-27T12:19:01Z
dc.date2015-11-27T12:19:01Z
dc.date.accessioned2018-03-29T00:52:21Z
dc.date.available2018-03-29T00:52:21Z
dc.identifierPathology, Research And Practice. v. 187, n. 8, p. 1031-5; discussion 1036-8, 1991-Dec.
dc.identifier0344-0338
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1792185
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194059
dc.identifier1792185
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294292
dc.descriptionThe report describes atypical multinucleated giant cells adjacent to proliferated nerve fascicles in a circumscribed subepithelial area of the cervix uteri of a 44-year-old multipara. Ultrastructural examination revealed cytoplasmatic processes, basal lamina, intracytoplasmic microfibrils, bizarre nuclear shapes with pseudoinclusions and nuclear fragments connected by small chromatin bridges (nucleotesimals). Immunohistochemical examination showed positive staining for vimentin and S-100 protein. Quantitative topography exhibited an isotropic distribution of the giant cells in an anisotropic architecture of mononuclear cells. A Schwann cell origin of the atypical giant cells is postulated. Aetiopathogenetically the lesion is regarded to be due to a trauma during delivery followed by regenerative proliferation of nerve fascicles and degenerative alterations of proliferating Schwann cells. The knowledge of this lesion is considered important, because the atypical cells could be confounded with malignant neoplastic cells.
dc.description187
dc.description1031-5; discussion 1036-8
dc.languageeng
dc.relationPathology, Research And Practice
dc.relationPathol. Res. Pract.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectCell Differentiation
dc.subjectCell Division
dc.subjectCervix Uteri
dc.subjectFemale
dc.subjectGiant Cells
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMicroscopy, Electron
dc.subjectS100 Proteins
dc.subjectSchwann Cells
dc.subjectVimentin
dc.titleAtypical Stromal Giant Cells Of Cervix Uteri--evidence Of Schwann Cell Origin.
dc.typeArtículos de revistas


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