Methodology And Instrumentation For The In Vitro Sinus Node Recovery Time Determination.

dc.creatorMarques, J L
dc.creatorBassani, R A
dc.creatorBassani, J W
dc.date1990-Apr
dc.date2015-11-27T12:18:36Z
dc.date2015-11-27T12:18:36Z
dc.date.accessioned2018-03-29T00:51:30Z
dc.date.available2018-03-29T00:51:30Z
dc.identifierJournal Of Pharmacological Methods. v. 23, n. 2, p. 117-27, 1990-Apr.
dc.identifier0160-5402
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/2332980
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193839
dc.identifier2332980
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294072
dc.descriptionIn the present work we describe a methodology and a low-cost instrument to determine the sinus node recovery time (SNRT) in the isolated rat right atrium. The instrumentation measures the SNRT using the continuous pacing method and the method of stimulation with premature pulses. When these methods were compared, we observed that the corrected SNRT (CSNRT = SNRT - the mean spontaneous cycle length, MCL) significantly (p less than 0.001) depended on the method used. The effects of norepinephrine (NE) and acetylcholine (ACh) on MCL and CSNRT were also analyzed. Although both neurotransmitters affected MCL (p less than 0.001), only in the presence of ACh a significant (p less than 0.05) correlation between CSNRT and MCL was found. In both methods, the CSNRT values were quite reproducible. The agreement between the data obtained and the predictions of the theoretical models for in vivo SNRT determination suggests that the present methodology may be useful for studies concerning physical and chemical influences on SNRT, as well as for the development of new stimulation tests.
dc.description23
dc.description117-27
dc.languageeng
dc.relationJournal Of Pharmacological Methods
dc.relationJ Pharmacol Methods
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAcetylcholine
dc.subjectAlgorithms
dc.subjectAnimals
dc.subjectArrhythmias, Cardiac
dc.subjectElectric Stimulation
dc.subjectElectrophysiology
dc.subjectHeart Rate
dc.subjectIn Vitro Techniques
dc.subjectMale
dc.subjectNorepinephrine
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectSinoatrial Node
dc.subjectSoftware
dc.titleMethodology And Instrumentation For The In Vitro Sinus Node Recovery Time Determination.
dc.typeArtículos de revistas


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