Artículos de revistas
Biosynthesis Of A Trypanocide By Chromobacterium Violaceum.
Registro en:
World Journal Of Microbiology & Biotechnology. v. 10, n. 6, p. 686-90, 1994-Nov.
0959-3993
10.1007/BF00327960
24421196
Autor
Durán, N
Antonio, R V
Haun, M
Pilli, R A
Institución
Resumen
Radio-isotope studies indicated not only that L-tryptophan can serve as carbon source for synthesis of the trypanocide, violacein by Chromobacterium violaceum (BB-78 strain) but also that isatin and indole 3-acetic acid are both important metabolic intermediates. Using 3-indolyl [2-(14)C] and [1-(14)C] acetic acid, it was found that the carboxylic carbon was not eliminated and that indole-3-acetic acid was incorporated intact into the pigment structure. N-Ethyl(5-hydroxy-indol-3-yl)-2-indolylethylamide is also an important metabolic intermediate in the violacein biosynthesis. This is the first report of a metabolic scheme for violacein synthesis which includes an intermediate other than L-tryptophan. 10 686-90