Artículos de revistas
Pharmacokinetic Profile Of Two Different Pharmaceutical Forms Of Theophylline (a Slow Release Tablet And A Syrup) After Multiple Dose Administration To Healthy Human Volunteers.
Registration in:
Memórias Do Instituto Oswaldo Cruz. v. 88, n. 1, p. 155-8
0074-0276
8246751
Author
Muscará, M N
Hofstätter, E A
de Nucci, G
Institutions
Abstract
Due to the narrow therapeutic range of theophylline, plasma concentrations of this drug are monitored in patients undergoing chronic therapy. Slow-release preparations avoid the fluctuations in plasma levels and improve patient compliance. In this study, we have compared the pharmacokinetic profiles of a theophylline slow-release tablet and a syrup form, when administered in multiple doses to healthy adult volunteers. The classification based upon releasing patterns is confirmed. 88 155-8