Involvement Of Lipoxygenase And Cyclo-oxygenase Pathways In Hypoxia And Metabolic Alkalosis Produced By Canatoxin In Rats.

dc.creatorCollares, C B
dc.creatorRibeiro-da-Silva, G
dc.date1988
dc.date2015-11-27T12:10:00Z
dc.date2015-11-27T12:10:00Z
dc.date.accessioned2018-03-29T00:50:32Z
dc.date.available2018-03-29T00:50:32Z
dc.identifierBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 21, n. 1, p. 107-10, 1988.
dc.identifier0100-879X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/3140990
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/193591
dc.identifier3140990
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1293824
dc.descriptionThis paper reports on the metabolic alkalosis produced in rats by canatoxin, a neurotoxic principle extracted from Canavalia ensiformis seeds. Rats receiving canatoxin showed increased blood bicarbonate concentration with alkaline pH and no change in pCO2. A fall in pO2 was also seen. A dose-dependent relationship between pO2 decrease and bicarbonate increase was also observed with the toxin, suggesting that hypoxia may result from respiratory compensation. Canatoxin-induced hypoxia was both lipoxygenase and cyclo-oxygenase dependent but metabolic alkalosis was only blocked with cyclo-oxygenase inhibitors. Canatoxin activates the lipoxygenase pathway and probably increases leukotriene (LT) production. Since LT may release cyclo-oxygenase products, this may explain the metabolic alkalosis observed with canatoxin.
dc.description21
dc.description107-10
dc.languageeng
dc.relationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]
dc.relationBraz. J. Med. Biol. Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAcid-base Equilibrium
dc.subjectAlkalosis
dc.subjectAnimals
dc.subjectAnoxia
dc.subjectBicarbonates
dc.subjectHydrogen-ion Concentration
dc.subjectLectins
dc.subjectLipoxygenase
dc.subjectMale
dc.subjectPlant Proteins
dc.subjectProstaglandin-endoperoxide Synthases
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectToxins, Biological
dc.titleInvolvement Of Lipoxygenase And Cyclo-oxygenase Pathways In Hypoxia And Metabolic Alkalosis Produced By Canatoxin In Rats.
dc.typeArtículos de revistas


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