Artículos de revistas
Hancornia speciosa: Indications of gastroprotective, healing and anti-Helicobacter pylori actions
Registro en:
Journal Of Ethnopharmacology. Elsevier Ireland Ltd, v. 120, n. 2, n. 161, n. 168, 2008.
0378-8741
WOS:000261520900006
10.1016/j.jep.2008.08.001
Autor
Moraes, TDM
Rodrigues, CM
Kushima, H
Bauab, TM
Villegas, W
Pellizzon, CH
Brito, ARMS
Hiruma-Lima, CA
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Ethnophamacological relevance: Mangaba(Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomachache. Aim of the study: The hydroalcoholic extract (HE) and infusion (BI) of Hancornia speciosa bark were investigated for their ability to prevent and heal rodent gastric Ulcer. Materials and methods: The preventive and healing action of both preparations of Hancornia speciosa were evaluated in experimental models in rodents that simulated this disease in human gastric mucosa. Results: BI did not exert gastroprotective effect, in contrast to FIE (500 mg/kg, p.o.) that decreased (p < 0.05) the severity of gastric damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). HE increased (p<0.05) the pH and decreased acid output of gastric juice. This extract promoted increase of mucus amount (3.62 mg/wt. tissue vs. 5.81 mg/wt. tissue), healing action (67%) and displayed anti-Helicobacter pylori effect. Conclusions: The antiulcer action of Hancornia speciosa resulted in increase of gastric mucus formation and antioxidant properties of polymeric proanthocyanidins present in the bark composition of this medicinal plant. Published by Elsevier Ireland Ltd 120 2 161 168 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [00102772-0]