Artículos de revistas
beta-catenin and E-cadherin expression in salivary gland tumors
Registro en:
International Journal Of Surgical Pathology. Sage Publications Inc, v. 14, n. 3, n. 212, n. 217, 2006.
1066-8969
WOS:000239776300005
10.1177/1066896906290652
Autor
Furuse, C
Cury, PR
Altemani, A
Pinto, DD
de Araujo, NS
de Araujo, VC
Institución
Resumen
This study evaluated the expression of E-cadherin and beta-catenin in salivary gland tumors. Twelve biopsy specimens from cases diagnosed as pleomorphic adenoma, 17 adenoid cystic carcinomas, 10 epithelial-myoepithelial carcinomas, and 4 polymorphous low-grade adenocarcinomas were inummohistochemically labeled for E-cadherin and beta-catenin antibodies. Healthy salivary glands were used as controls. Membrane-associated E-cadherin and beta-catenin expression was present in all the tumor types studied. E-cadherin and beta-catenin showed a similar distribution; however, beta-catenin labeling was weaker than that for E-cadherin. In the epithelial-myoepithelial carcinomas, myoepithelial cells exhibited diffuse nuclear staining, although occasional cells presented only focal labeling. Epithelial-myoepithelial carcinomas present changes in beta-catenin expression but the other salivary tumors studied do not, which may reflect divergence in tumorigenesis of this extensive subset of salivary gland tumors. 14 3 212 217