Artículos de revistas
Lymphocyte activation in silica-exposed workers
Registro en:
International Journal Of Hygiene And Environmental Health. Elsevier Gmbh, Urban & Fischer Verlag, v. 217, n. 41763, n. 586, n. 591, 2014.
1438-4639
1618-131X
WOS:000335113500018
10.1016/j.ijheh.2013.11.002
Autor
Rocha-Parise, M
Santos, LMB
Damoiseaux, JGMC
Bagatin, E
Lido, AV
Torello, CO
Tervaert, JWC
Queiroz, MLS
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, systemic lupus erythematosus and ANCA-associated vasculitis. However, the underlying cellular and molecular mechanisms resulting in the increased prevalence of autoimmunity remain elusive. To clarify these mechanisms, we studied various markers of immune activation in individuals occupationally exposed to silica dust, i.e., serum levels of soluble IL-2 receptor (sIL-2R), levels of IL-2, other pro- and anti-inflammatory cytokines and lymphoproliferation. Our results demonstrate that silica-exposed individuals present important alterations in their immune response when compared to controls, as shown by increased serum sIL-2R levels, decreased production of IL-2 and increased levels of the pro-inflammatory (IFN-gamma, IL-1 alpha, TNF-alpha, IL-6) as well as anti-inflammatory (IL-10 and TGF-beta) cytokines. Furthermore, silica-exposed individuals presented enhanced lymphoproliferative responses. Our findings provide evidence that the maintenance of immune homeostasis may be disturbed in silica-exposed individuals, possibly resulting in autoimmune disorders. (C) 2013 Elsevier GmbH. All rights reserved. 217 41763 586 591 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [2001/13823-8, 2007/53901-4] CNPq [301702/2005-5, 300575/2008-4]