Artículos de revistas
Synthesis and rational design of anti-inflammatory compounds: N-phenyl-cyclohexenyl sulfonamide derivatives
Registro en:
Journal Of Physical Organic Chemistry. John Wiley & Sons Ltd, v. 22, n. 12, n. 1188, n. 1192, 2009.
0894-3230
WOS:000272727700008
10.1002/poc.1575
Autor
Lloret, GR
Neto, AC
Rittner, R
Bitencourt, M
Freitas, MP
Aquino, NS
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The synthesis of (+/-)-ethyl 6-[N-(2-chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (5n) has been reproduced from a method previously described and served as the background for the preparation of a nitro derivative, potentially useful as an anti-inflammatory agent. Furthermore, a structure-based QSAR analysis of a series of N-arylsulfamoyl congeners derived a highly predictive model for the activities of novel small-molecule inhibitors of NO and cytokine production, whose preparation may be successfully achieved according to a similar procedure as above. Copyright (C) 2009 John Wiley & Sons, Ltd. 22 12 1188 1192 Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPEMIG [CEX 415/06] FAPESP [2005/59649-0]