Artículos de revistas
A convenient synthesis by microwave irradiation of an active metabolite (EXP-3174) of losartan
Registro en:
Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 44, n. 6, n. 1149, n. 1152, 2003.
0040-4039
WOS:000180731300007
10.1016/S0040-4039(02)02835-6
Autor
Santagada, V
Fiorino, F
Perissutti, E
Severino, B
Terracciano, S
Teixeira, CE
Caliendo, G
Institución
Resumen
A novel and convenient microwave-assisted synthesis of an active metabolite (EXP-3174) of losartan is described. Room temperature and microwave irradiation of the reactions are compared. Synthesis by microwave irradiation gave the desired compound in higher yields and in shorter reaction times than those obtained at room temperature. (C) 2003 Elsevier Science Ltd. All rights reserved. 44 6 1149 1152