Long-term assessment of forearm bone mineral density in postmenopausal former users of depot medroxyprogesterone acetate

dc.creatorViola, AS
dc.creatorCastro, S
dc.creatorMarchi, NM
dc.creatorBahamondes, MV
dc.creatorViola, CFM
dc.creatorBahamondes, L
dc.date2011
dc.dateAUG
dc.date2014-07-30T13:38:52Z
dc.date2015-11-26T17:56:53Z
dc.date2014-07-30T13:38:52Z
dc.date2015-11-26T17:56:53Z
dc.date.accessioned2018-03-29T00:40:28Z
dc.date.available2018-03-29T00:40:28Z
dc.identifierContraception. Elsevier Science Inc, v. 84, n. 2, n. 122, n. 127, 2011.
dc.identifier0010-7824
dc.identifierWOS:000293200500003
dc.identifier10.1016/j.contraception.2010.11.007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52617
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/52617
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1291353
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBackground: There are many controversies on the association between depot medroxyprogesterone acetate (DMPA) and bone mineral density (BMD). This study reevaluated BMD in postmenopausal women who had used DMPA as a contraceptive until they reached menopause and compared them with non-users. BMD had previously been measured in these women either at 1 year or 2-3 years after menopause and was reassessed in these women 2 years later. Therefore, comparisons were made between the first and third years and between the second to third and fourth to fifth years after menopause. Study Design: BMD was reevaluated using dual-energy X-ray absorptiometry at two parts of the non-dominant forearm up to 5 years after menopause in 79 women between 46 and 61 years old: 24 former DMPA users and 55 former copper intrauterine device (IUD) users. Results: With respect to the former DMPA users, only the BMD measurement at the distal radius in the first year (mean SEM, 0.425 +/- 0.017) was significantly higher than the third-year measurement (0.406 +/- 0.017) (p<.015). No significant differences were found at the ultradistal radius. There were no significant differences between the groups of former DMPA and IUD users with respect to BMD measurements either at the distal radius or at the ultradistal radius. There was a direct relationship between higher body mass index (kg/m(2)) and higher BMD at the distal radius between the first and third years. At the ultradistal radius, there was an indirect relationship between older age and lower BMD between the first and third years in both groups. Conclusions: No statistically significant differences were found in forearm BMD measurements between postmenopausal women who had been long-term users of DMPA and those who had been long-term users of an IUD until menopause. Evaluation of BMD after the menopause showed slightly higher values in former DMPA users compared with non-users. (C) 2011 Elsevier Inc. All rights reserved.
dc.description84
dc.description2
dc.description122
dc.description127
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [573747/2008-3]
dc.languageen
dc.publisherElsevier Science Inc
dc.publisherNew York
dc.publisherEUA
dc.relationContraception
dc.relationContraception
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectBone mineral density
dc.subjectDepot medroxyprogesterone acetate
dc.subjectMenopause
dc.subjectHormonal Contraception
dc.subjectOsteoporotic Fractures
dc.subjectOral-contraceptives
dc.subjectWomen
dc.subjectAdolescents
dc.subjectRecovery
dc.subjectCohort
dc.subjectHealth
dc.subjectDmpa
dc.subjectMass
dc.titleLong-term assessment of forearm bone mineral density in postmenopausal former users of depot medroxyprogesterone acetate
dc.typeArtículos de revistas


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