Artículos de revistas
Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
Registro en:
Biomedical Optics Express. Optical Soc Amer, v. 4, n. 7, n. 978, n. 994, 2013.
2156-7085
WOS:000321336500001
10.1364/BOE.4.000978
Autor
Mesquita, RC
Schenkel, SS
Minkoff, DL
Lu, XP
Favilla, CG
Vora, PM
Busch, DR
Chandra, M
Greenberg, JH
Detre, JA
Yodh, AG
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues. (C) 2013 Optical Society of America 4 7 978 994 National Institutes of Health (NIH) [R01-NS060653, K24-NS058386, P41-EB015893] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) National Institutes of Health (NIH) [R01-NS060653, K24-NS058386, P41-EB015893] FAPESP [2012/02500-8]