A silver complex with ibuprofen: Synthesis, solid state characterization, DFT calculations and antibacterial assays

dc.creatore Silva, IMP
dc.creatorProfirio, DD
dc.creatorde Paiva, REF
dc.creatorLancellotti, M
dc.creatorFormiga, ALB
dc.creatorCorbi, PP
dc.date2013
dc.dateOCT 8
dc.date2014-07-30T13:42:50Z
dc.date2015-11-26T17:51:10Z
dc.date2014-07-30T13:42:50Z
dc.date2015-11-26T17:51:10Z
dc.date.accessioned2018-03-29T00:34:32Z
dc.date.available2018-03-29T00:34:32Z
dc.identifierJournal Of Molecular Structure. Elsevier Science Bv, v. 1049, n. 1, n. 6, 2013.
dc.identifier0022-2860
dc.identifierWOS:000324784700001
dc.identifier10.1016/j.molstruc.2013.06.034
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53752
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53752
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1289908
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe present work describes the synthesis of a silver(I) complex with the non-steroidal anti-inflammatory ibuprofen, Ag-ibu. Elemental and thermal analyses indicate a 1:1 metal/ligand composition. Thermogravimetric analysis shows that Ag-ibu decomposition starts at 180 degrees C, and ends at 400 degrees C (mass loss 64.6%; calcd. 65.5%). UV/Vis kinetic measurements suggest the decomposition of Ag-ibu in dimethyl sulfoxide, with the appearance of a broad band in the spectrum of the complex in the range 300-500 nm. Infrared and solid state C-13 NMR spectra show the coordination of ibuprofen to silver through the carboxylate group. The DFT calculations led us to. propose a dimeric silver bridging structure for the complex. Biological studies show the antibacterial activity of the Ag-ibu complex against Gram-positive and Gram-negative bacterial strains, with MIC values ranging from 6.25 to 12.5 mu g mL(-1). (c) 2013 Elsevier B.V. All rights reserved.
dc.description1049
dc.description1
dc.description6
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2012/08230-2]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationJournal Of Molecular Structure
dc.relationJ. Mol. Struct.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectIbuprofen
dc.subjectSilver
dc.subjectSolid-state NMR
dc.subjectMass spectrometry
dc.subjectTheoretical calculations
dc.subjectAntibacterial agent
dc.subjectMolecular-orbital Methods
dc.subjectGaussian-type Basis
dc.subjectAnticancer Activity
dc.subjectCrystal-structures
dc.subjectOrganic-molecules
dc.subjectDensity
dc.subjectDrugs
dc.subjectAcid
dc.subjectNanoparticles
dc.subjectAcetate
dc.titleA silver complex with ibuprofen: Synthesis, solid state characterization, DFT calculations and antibacterial assays
dc.typeArtículos de revistas


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