Artículos de revistas
PHARMACOKINETIC PROFILE OF 2 DIFFERENT PHARMACEUTICAL FORMS OF THEOPHYLLINE (A SLOW-RELEASE TABLET AND A SYRUP) AFTER MULTIPLE-DOSE ADMINISTRATION TO HEALTHY-HUMAN VOLUNTEERS
Registro en:
Memorias Do Instituto Oswaldo Cruz. Mem Inst Oswaldo Cruz, v. 88, n. 1, n. 155, n. 158, 1993.
0074-0276
WOS:A1993LB71000024
Autor
MUSCARA, MN
HOFSTATTER, EA
DENUCCI, G
Institución
Resumen
Due to the narrow therapeutic range of theophylline, plasma concentrations of this drug are monitored in patients undergoing chronic therapy. Slow-release preparations avoid the fluctuations in plasma levels and improve patient compliance. In this study, we have compared the pharmacokinetic profiles of a theophylline slow-release tablet and a syrup form, when administered in multiple doses to healthy adult volunteers. The classification based upon releasing patterns is confirmed. 88 1 155 158