Artículos de revistas
IL10 inversely correlates with the percentage of CD8(+) cells in MDS patients
Registro en:
Leukemia Research. Pergamon-elsevier Science Ltd, v. 37, n. 5, n. 541, n. 546, 2013.
0145-2126
WOS:000317264500012
10.1016/j.leukres.2013.01.019
Autor
Lopes, MR
Traina, F
Campos, PD
Pereira, JKN
Machado-Neto, JA
Machado, HD
Gilli, SCO
Saad, STO
Favaro, P
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4(+) and CD8(+) lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGF beta 1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8(+) cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. (C) 2013 Elsevier Ltd. All rights reserved. 37 5 541 546 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)