Artículos de revistas
Downregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation
Registro en:
Leukemia Research. Pergamon-elsevier Science Ltd, v. 36, n. 7, n. 931, n. 935, 2012.
0145-2126
WOS:000304353400034
10.1016/j.leukres.2012.03.002
Autor
Machado-Neto, JA
Favaro, P
Lazarini, M
Duarte, ADS
Archangelo, LF
Lorand-Metze, I
Costa, FF
Saad, STO
Traina, F
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Insulin receptor substrate 2 (IRS2) is an adaptor protein that associates with the receptor of erythropoietin, insulin-like growth factor 1 and thrombopoietin; however, its role is not known in myelodysplasia. We, herein, report a significantly lower IRS2 expression in MDS cells, compared to normal cells. IRS2 expression was reduced in high-risk, compared to low-risk disease, and positively correlated with neutrophil and platelet counts. IRS2 was upregulated during erythroid differentiation of CD34(+) cells from normal donors and low-risk MDS patients and also during erythroid, granulocytic and megakaryocytic differentiation in cell lines. These results suggest that defective IRS2 expression plays a role in the impaired hematopoietic cell differentiation in MDS. (C) 2012 Elsevier Ltd. All rights reserved. 36 7 931 935 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)