Differences in gastroprotective and mutagenic actions between polar and apolar extracts of Ananas ananassoides

dc.creatorSilva, JS
dc.creatorAndreo, MA
dc.creatorTubaldini, FR
dc.creatorVaranda, EA
dc.creatorRocha, LRM
dc.creatorBrito, ARMS
dc.creatorVilegas, W
dc.creatorHiruma-Lima, CA
dc.date2008
dc.date2014-07-30T14:43:27Z
dc.date2015-11-26T17:39:32Z
dc.date2014-07-30T14:43:27Z
dc.date2015-11-26T17:39:32Z
dc.date.accessioned2018-03-29T00:21:06Z
dc.date.available2018-03-29T00:21:06Z
dc.identifierJournal Of Medicinal Food. Mary Ann Liebert Inc, v. 11, n. 1, n. 160, n. 168, 2008.
dc.identifier1096-620X
dc.identifierWOS:000257000900022
dc.identifier10.1089/jmf.2007.508
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61757
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61757
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1286473
dc.descriptionSeveral plants are used in folk medicine to treat gastrointestinal disorders. Ananas ananassoides (Baker) L. B. Smith (Family Bromeliaceae) is a medicinal plant commonly used in the central region of Brazil against gastric pain. We evaluated two extracts (methanol [MeOH] and dichloromethane [DCM]) obtained from the leaves of A. ananassoides for their ability to protect the gastric mucosa against injuries caused by necrotizing agents (0.3 M HCl/60% ethanol, absolute ethanol, non-steroidal anti-inflammatory drugs, and pylorus ligation) in mice and rats. The best results were obtained after pretreatment with the DCM extract, whereas the MeOH extract did not show any significant anti-ulcerogenic activity but presented mutagenic action. The mechanism of action of the DCM extract suggested the effective participation of endogenous sulfhydryl group in the gastroprotective action. The data, taken together with the absence of acute toxicity and mutagenicity, indicate the apolar extract, instead of the polar, extract of A. ananassoides as a safe and potential new anti-ulcerogenic drug.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description11
dc.description1
dc.description160
dc.description168
dc.languageen
dc.publisherMary Ann Liebert Inc
dc.publisherNew Rochelle
dc.publisherEUA
dc.relationJournal Of Medicinal Food
dc.relationJ. Med. Food
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectAnanas ananassoides
dc.subjectanti-ulcerogenic activity
dc.subjectBromeliaceae
dc.subjectendogenous sulfhydryls
dc.subjectmutagenicity
dc.subjectInduced Gastric-lesions
dc.subjectNitric-oxide
dc.subjectRats
dc.subjectAssay
dc.subjectProstaglandins
dc.subjectPathogenesis
dc.subjectSulfhydryls
dc.subjectRanitidine
dc.subjectProtection
dc.subjectPiroxicam
dc.titleDifferences in gastroprotective and mutagenic actions between polar and apolar extracts of Ananas ananassoides
dc.typeArtículos de revistas


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