Artículos de revistas
An efficient synthesis of (R)-(-)-baclofen
Registro en:
Tetrahedron-asymmetry. Pergamon-elsevier Science Ltd, v. 10, n. 11, n. 2113, n. 2118, 1999.
0957-4166
WOS:000081832200009
10.1016/S0957-4166(99)00235-9
Autor
Resende, P
Almeida, WP
Coelho, F
Institución
Resumen
In this report we describe an efficient synthesis of (R)-(-)-baclofen, a selective GABA(B) agonist used as an antispastic agent. Our strategy is based on an enantioselective deprotonation of a cyclobutanone easily obtained by [2+2] cycloaddition of 4-chlorostyrene and dichloroketene. (C) 1999 Published by Elsevier Science Ltd. All rights reserved. 10 11 2113 2118