Optimization of N, N, N-trimethylchitosan synthesis by factorial design

dc.creatorde Britto, D
dc.creatorFrederico, FR
dc.creatorAssis, OBG
dc.date2011
dc.dateJUN
dc.date2014-08-01T18:37:47Z
dc.date2015-11-26T17:30:33Z
dc.date2014-08-01T18:37:47Z
dc.date2015-11-26T17:30:33Z
dc.date.accessioned2018-03-29T00:17:29Z
dc.date.available2018-03-29T00:17:29Z
dc.identifierPolymer International. Wiley-blackwell, v. 60, n. 6, n. 910, n. 915, 2011.
dc.identifier0959-8103
dc.identifierWOS:000291062100007
dc.identifier10.1002/pi.3038
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81676
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81676
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1285546
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFactorial design analysis was applied to optimize the synthesis, via a new route, of N, N, N-trimethylchitosan, based on dimethylsulfate as a methylating agent. The responses analyzed were weight yield, solubility and average degree of quaternization. Temperature was verified as the most important variable, as it caused the most variation in the response. X(T) = -54.52,-9.50 and -7.25, respectively, for weight yield, solubility and degree of quaternization. A sharp decrease in the viscosimetric and gel permeation chromatography parameters proved that severe depolymerization took place at high reaction temperatures. Contact angle measurements showed a decrease in the hydrophilic character of over-methylated samples. (C) 2011 Society of Chemical Industry
dc.description60
dc.description6
dc.descriptionSI
dc.description910
dc.description915
dc.descriptionEMBRAPA
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationPolymer International
dc.relationPolym. Int.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectoptimization
dc.subjectfactorial design
dc.subjectN, N, N-trimethylchitosan
dc.subjectGPC
dc.subjectmolecular weight
dc.subjectQuaternary Ammonium-salt
dc.subjectBiological-properties
dc.subjectChitosan Chloride
dc.subjectIn-vitro
dc.subjectN,n,n-trimethylchitosan
dc.subjectTmc
dc.subjectQuaternization
dc.subjectDeacetylation
dc.subjectNanoparticles
dc.subjectDelivery
dc.titleOptimization of N, N, N-trimethylchitosan synthesis by factorial design
dc.typeArtículos de revistas


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