| dc.creator | Menezes, FAS | |
| dc.creator | Montanari, CA | |
| dc.creator | Bruns, RE | |
| dc.date | 2000 | |
| dc.date | JUL-AUG | |
| dc.date | 2014-12-02T16:26:14Z | |
| dc.date | 2015-11-26T17:27:40Z | |
| dc.date | 2014-12-02T16:26:14Z | |
| dc.date | 2015-11-26T17:27:40Z | |
| dc.date.accessioned | 2018-03-29T00:14:49Z | |
| dc.date.available | 2018-03-29T00:14:49Z | |
| dc.identifier | Journal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 11, n. 4, n. 393, n. 397, 2000. | |
| dc.identifier | 0103-5053 | |
| dc.identifier | WOS:000089337600012 | |
| dc.identifier | 10.1590/S0103-50532000000400012 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52646 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/52646 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/52646 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1284856 | |
| dc.description | A proposed model for the interaction of bisamidine analogues with the B-DNA receptor is established by structure-property relationship studies derived from 3D-WHIM descriptor calculations. Three classes, each with relevant information about structural relationships, were determined by PCA and SIMCA analyses for molecular conformations described by 3D-WHIM descriptors for a set of 29 bisamidines with antileishmaniasis and anti-PCP activities. Shape, distribution and dimension properties mostly govern the interaction of bisamidines with B-DNA through the minor groove AT rich regions. | |
| dc.description | 11 | |
| dc.description | 4 | |
| dc.description | 393 | |
| dc.description | 397 | |
| dc.language | en | |
| dc.publisher | Soc Brasileira Quimica | |
| dc.publisher | Sao Paulo | |
| dc.publisher | Brasil | |
| dc.relation | Journal Of The Brazilian Chemical Society | |
| dc.relation | J. Braz. Chem. Soc. | |
| dc.rights | aberto | |
| dc.source | Web of Science | |
| dc.subject | 3D-QSAR | |
| dc.subject | principal component analysis | |
| dc.subject | pattern recognition | |
| dc.subject | Pneumocystis-carinii Pneumonia | |
| dc.subject | Minor-groove Recognition | |
| dc.subject | Whim Descriptors | |
| dc.subject | Nucleic-acids | |
| dc.subject | Pentamidine | |
| dc.subject | Analogs | |
| dc.subject | Leishmania | |
| dc.subject | Hoechst-33258 | |
| dc.subject | Amazonensis | |
| dc.subject | Prediction | |
| dc.title | 3D-WHIM pattern recognition study for bisamidines. A structure-property relationship study. | |
| dc.type | Artículos de revistas | |
