CLASSICAL AVERSIVE CONDITIONING INDUCES INCREASED EXPRESSION OF MATURE-BDNF IN THE HIPPOCAMPUS AND AMYGDALA OF PIGEONS

dc.creatorFaria, RS
dc.creatorSartori, CR
dc.creatorCanova, F
dc.creatorFerrari, EAM
dc.date2013
dc.dateDEC 26
dc.date2014-07-30T13:59:37Z
dc.date2015-11-26T17:26:43Z
dc.date2014-07-30T13:59:37Z
dc.date2015-11-26T17:26:43Z
dc.date.accessioned2018-03-29T00:13:53Z
dc.date.available2018-03-29T00:13:53Z
dc.identifierNeuroscience. Pergamon-elsevier Science Ltd, v. 255, n. 122, n. 133, 2013.
dc.identifier0306-4522
dc.identifier1873-7544
dc.identifierWOS:000330591500011
dc.identifier10.1016/j.neuroscience.2013.09.054
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55957
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55957
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1284616
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe expression of brain-derived neurotrophic factor (BDNF), which is found in the pro-BDNF, truncatedBDNF and mature-BDNF isoforms, changes with learning. Mature-BDNF shows a peak of late expression in the hippocampus that is involved in the persistence of aversive memory in rodents. However, the role of BDNF in the hippocampal synaptic mechanisms involved in the classical conditioning aversive memory in birds still needs clarification. This study investigated the late expression of BDNF in the hippocampus and amygdala of pigeons trained with tone-shock conditioning and the effects of intra-hippocampal infusion of anisomycin (Ani) in these changes. Seven days after implantation of intra-hippocampal microcannulae, adult pigeons trained with three tone-shock pairings were assigned to one of three groups: Conditioning and Ani (CondANI), Conditioning and saline vehicle (CondSAL) and Conditioning only (Cond). NAIVE group had no treatment or conditioning. Homogenates of tissues from the hippocampus and amygdala, obtained 12 h after training, were used to determine the content of mature-BDNF, truncatedBDNF and pro-BDNF using Western blotting. Higher values for mature-BDNF than for truncated-and pro-BDNF content were seen in the hippocampus of Cond and CondSAL birds, but not in the hippocampus of CondANI or NAIVE birds (p < 0.05). The values of mature-BDNF in the amygdala of all the three conditioned groups were higher than those observed for truncated-and pro-BDNF (p < 0.05), which indicates that the activation of this protein in the amygdala was not affected by the infusion of Ani in the hippocampus. The data indicate that the tone-shock conditioning induced the activation of molecular pathways of BDNF in the hippocampus and amygdala of the pigeons. The decreases in the content of truncated- and pro-BDNF isoforms found in conditioned pigeons may suggest cleavage mechanisms induced by the training. Our data confirm previous observations of rodent studies and extend these observations to pigeons, revealing that, in spite of the anatomical differences between the hippocampus of rodents and pigeons, there are functional and molecular mechanisms that are conservative between the species. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
dc.description255
dc.description122
dc.description133
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [CNPq/304933-2012-0]
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationNeuroscience
dc.relationNeuroscience
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectclassical aversive conditioning
dc.subjecthippocampus
dc.subjectamygdala
dc.subjectpro-BDNF
dc.subjecttruncated-BDNF
dc.subjectmature-BDNF
dc.subjectTissue-plasminogen Activator
dc.subjectLong-term-memory
dc.subjectDifferent Anterograde Amnesias
dc.subjectNeurotrophic Factor
dc.subjectSynaptic Plasticity
dc.subjectVentral Hippocampus
dc.subjectGene-transcription
dc.subjectSpatial Memory
dc.subjectFear Memory
dc.subjectBrain
dc.titleCLASSICAL AVERSIVE CONDITIONING INDUCES INCREASED EXPRESSION OF MATURE-BDNF IN THE HIPPOCAMPUS AND AMYGDALA OF PIGEONS
dc.typeArtículos de revistas


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