Prostatic stromal microenvironment and experimental diabetes

dc.creatorRibeiro, DL
dc.creatorCaideira, EJ
dc.creatorCandido, EM
dc.creatorManzato, M
dc.creatorTaboga, SR
dc.creatorCagnon, VH
dc.date2006
dc.dateJAN-MAR
dc.date2014-11-16T06:30:45Z
dc.date2015-11-26T17:23:40Z
dc.date2014-11-16T06:30:45Z
dc.date2015-11-26T17:23:40Z
dc.date.accessioned2018-03-29T00:10:58Z
dc.date.available2018-03-29T00:10:58Z
dc.identifierEuropean Journal Of Histochemistry. Luigi Ponzio E Figlio, v. 50, n. 1, n. 51, n. 60, 2006.
dc.identifier1121-760X
dc.identifierWOS:000236448900008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58287
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58287
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58287
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283882
dc.descriptionThe diabetes causes alterations in various organ systems, including the male accessory sex glands. The prostate is very important in the reproductive process and it is a frequent target of malignant changes, The aim of this work was to demonstrate the histochemical and ultrastructural alterations in the prostate of diabetic animals. Two groups of animals were utilized: control and non-obese diabetic mice (NOD). Twelve days after the characterization of diabetic status the ventral prostate was collected, fixed in Karnovsky and paraformaldehyde, processed for histochemistry and TEM associated to stereology. The results showed reduction of the epithelial area and increasing of the stromal area with muscular and collagen hypertrophy in the prostatic gland. It was characterized the development of prostatic intraepithelial neoplasia, inflammatory processes and dilation of the organelles involved in the secretory process. It was concluded that diabetes besides damaging the reproductive process, affects the glandular homeostasis favoring the development of prostatic pathologies.
dc.description50
dc.description1
dc.description51
dc.description60
dc.languageen
dc.publisherLuigi Ponzio E Figlio
dc.publisherPavia
dc.publisherItália
dc.relationEuropean Journal Of Histochemistry
dc.relationEur. J. Histochem.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectprostate
dc.subjectstroma
dc.subjectdiabetes
dc.subjectNOD mice
dc.subjecthistochemistry and ultrastructure
dc.subjectTissue-sections
dc.subjectRat Prostate
dc.subjectCancer
dc.subjectCarcinogenesis
dc.subjectMicroscopy
dc.subjectAndrogen
dc.titleProstatic stromal microenvironment and experimental diabetes
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución