Decrease of type IV collagen and TIMP-1 serum levels after splenectomy in patients with schistosomiasis mansoni

dc.creatorWyszomirska, RMAF
dc.creatorLacet, CD
dc.creatorTenorio, LR
dc.creatorNishimura, NF
dc.creatorMesquita, MA
dc.creatorNeto, JB
dc.creatorOliveira, F
dc.creatorBalwani, MDCL
dc.creatorAlmeida, JRS
dc.creatorSoares, EC
dc.date2006
dc.dateMAR
dc.date2014-11-15T22:57:39Z
dc.date2015-11-26T17:22:27Z
dc.date2014-11-15T22:57:39Z
dc.date2015-11-26T17:22:27Z
dc.date.accessioned2018-03-29T00:09:54Z
dc.date.available2018-03-29T00:09:54Z
dc.identifierActa Tropica. Elsevier Science Bv, v. 97, n. 3, n. 301, n. 308, 2006.
dc.identifier0001-706X
dc.identifierWOS:000236505300009
dc.identifier10.1016/j.actatropica.2005.12.004
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79345
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79345
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79345
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283607
dc.descriptionThe role of the spleen in the process of liver fibrosis in schistosomiasis still needs clarification. The aim of this Study was to assess the effect of splenectomy on serum levels of two markers of fibrosis, type IV collagen and TIMP-1, in patients with schistosomiasis mansoni. Twenty-four patients with hepatosplenic schistosomiasis mansoni participated in the study. Type IV collagen and TIMP-1 serum levels were measured preoperatively, and after 2 (POD-1) and 60 days (POD-2) of spleen removal. Before splenectomy, both type IV collagen and TIMP-1 serum levels were elevated in the majority of patients. After splenectomy, the levels of type IV collagen showed a significant decrease in relation to the preoperative values both in POD-1 (median pre-splenectomy: 143.7 ng/ml versus 77.01 ng/ml p = 0.04) and POD-2 (103.3 ng/ml; p = 0.015). Serum levels of TIMP-1 also showed a significant decrease in relation to the preoperative values both in POD-1 (pre-splenectomy: 585.9 ng/ml versus 196.4 ng/ml; p = 0.008) and POD-2 (97.4 ng/ml; p < 0.001). There was no difference between POD-land POD-2 values for each serum marker. In conclusion, splenectomy in schistosomotic patients was associated with it decrease in serum markers of fibrosis levels, which persisted for at least 60 days. These results suggest that the spleen may play a role in the extra cellular matrix production, and therefore may contribute to liver fibrosis in schistosomiasis mansoni. (c) 2006 Elsevier B.V. All rights reserved.
dc.description97
dc.description3
dc.description301
dc.description308
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationActa Tropica
dc.relationActa Trop.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectschistosomiasis mansoni
dc.subjectTIMP-1
dc.subjecttype IV collagen
dc.subjectspleen
dc.subjectliver fibrosis
dc.subjectT-cell-activation
dc.subjectLiver Fibrosis
dc.subjectHepatosplenic Schistosomiasis
dc.subjectMurine Schistosomiasis
dc.subjectMatrix Metalloproteinases
dc.subjectSpleen
dc.subjectExpression
dc.subjectInhibitors
dc.subjectMarkers
dc.subjectGranuloma
dc.titleDecrease of type IV collagen and TIMP-1 serum levels after splenectomy in patients with schistosomiasis mansoni
dc.typeArtículos de revistas


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