Crotapotin induced modification of T lymphocyte proliferative response through interference with PGE(2) synthesis

dc.creatorGarcia, F
dc.creatorToyama, MH
dc.creatorCastro, FR
dc.creatorProenca, PL
dc.creatorMarangoni, S
dc.creatorSantos, LMB
dc.date2003
dc.dateSEP 15
dc.date2014-11-15T21:47:52Z
dc.date2015-11-26T17:22:09Z
dc.date2014-11-15T21:47:52Z
dc.date2015-11-26T17:22:09Z
dc.date.accessioned2018-03-29T00:09:37Z
dc.date.available2018-03-29T00:09:37Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 42, n. 4, n. 433, n. 437, 2003.
dc.identifier0041-0101
dc.identifierWOS:000186083700013
dc.identifier10.1016/S0041-0101(03)00198-3
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57425
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/57425
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57425
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283540
dc.descriptionThe immunosuppressive property has been demonstrated for the venom of the Crotalus durissus terrificus. Using a simple, novel method for obtaining crotapotin and phospholipase A(2) isoforms from venom, it was possible to demonstrate that the addition of crotapotin to cultures of isolated lymphocytes resulted in a significant inhibition of the cellular proliferative response to Concanavalin A. This reduction in blastogenic response of lymphocytes is accompanied by a significant increase in the production of PGE(2) by macrophages. This effect on the innate immune response suggests that this compound may modify the subsequent adaptative immune response. (C) 2003 Elsevier Ltd. All rights reserved.
dc.description42
dc.description4
dc.description433
dc.description437
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectT cell activation
dc.subjectinflammatory response
dc.subjectcrotapotin
dc.subjectIntestinal Epithelial-cells
dc.subjectProstaglandin E-2
dc.subjectPhospholipase A(2)
dc.subjectInhibition
dc.subjectCyclooxygenase-2
dc.subjectInterleukin-4
dc.subjectInflammation
dc.subjectMacrophages
dc.subjectExpression
dc.subjectMechanisms
dc.titleCrotapotin induced modification of T lymphocyte proliferative response through interference with PGE(2) synthesis
dc.typeArtículos de revistas


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