Artículos de revistas
Crystal structure of the Kunitz (STI)-type inhibitor from Delonix regia seeds
Registro en:
Biochemical And Biophysical Research Communications. Academic Press Inc Elsevier Science, v. 312, n. 4, n. 1303, n. 1308, 2003.
0006-291X
WOS:000187252300066
10.1016/j.bbrc.2003.11.062
Autor
Krauchenco, S
Pando, SC
Marangoni, S
Polikarpov, I
Institución
Resumen
The three-dimensional structure of a novel Kunitz (STI) family member, an inhibitor purified from Delonix regia seeds.(DrTI), was solved by molecular replacement method and refined, respectively, to R-factor and R-free values of 21.5% and 25.3% at 1.75 Angstrom resolution. The structure has a classical beta-trefoil fold, however, differently from canonical Kunitz type (STI) inhibitors, its reactive site loop has an insertion of one residue, Glu68, between the residues P1 and P2. Surprisingly, DrTI is an effective inhibitor of trypsin and human plasma kallikrein, but not of chymotrypsin and tissue kallikrein. Putative structural grounds of such specificity are discussed. (C) 2003 Elsevier Inc. All rights reserved. 312 4 1303 1308
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors
Reis J.; Cagide F.; Valencia M.E.; Teixeira J.; Bagetta D.; Pérez C.; Uriarte E.; Oliveira P.J.; Ortuso F.; Alcaro S.; Rodríguez-Franco M.I.; Borges F. (Elsevier Masson SAS, 2018) -
SGLT-2 inhibitors for people with type 2 diabetes.
Autor desconocido (Elsevier, 2019)Evidence that sodium-glucose co-transporter-2 inhibitors (SGLT2i) can reduce cardiovascular risk—with trials showing reductions in cardiovascular death, myocardial infarction, and stroke—would suggest they have much to ... -
Environmental enrichment reverses tyrosine kinase inhibitor-mediated impairment through BDNF-TrkB pathway
Bengoetxea H.; Rico-Barrio I.; Ortuzar N.; Murueta-Goyena A.; Lafuente J.V. (Humana Press Inc., 2018)