Artículos de revistas
HIV-1 anti-retroviral drug effect on the C-albicans hyphal growth rate by a bio-cell tracer system
Registro en:
Brazilian Journal Of Microbiology. Soc Brasileira Microbiologia, v. 37, n. 3, n. 225, n. 229, 2006.
1517-8382
WOS:000243335200006
Autor
de Melo, NR
Vilela, MMS
Jorge, J
Kamei, K
Miyaji, M
Fukushima, K
Nishimura, K
Groeneveld, P
Kelly, SL
Taguchi, H
Institución
Resumen
Declining incidence of oropharyngeal candidosis and opportunistic infections over recent years can be attributed to the use of highly active anti-retroviral therapy ( HAART). Infection with C. albicans generally involves adherence and colonization of superficial tissues. During this process, budding yeasts are able to transform to hyphae and penetrate into the deep tissue. Using the biocell tracer system, C. albicans hyphal growth was dynamically observed at the cellular level. Ritonavir was effective in the inhibition of hyphal growth with growth rate of 0.8 mu m/min. This study showed the in vitro effect of HIV anti-retroviral drug on the growth rate of the C. albicans hyphae. 37 3 225 229