Oral avascular bone necrosis associated with chemotherapy and biphosphonate therapy

dc.creatorPires, FR
dc.creatorMiranda, AMMA
dc.creatorCardoso, ES
dc.creatorCardoso, AS
dc.creatorFregnani, ER
dc.creatorPereira, CM
dc.creatorCorrea, MEP
dc.creatorAlmeida, JP
dc.creatorAlves, FD
dc.creatorLopes, MA
dc.creatorde Almeida, OP
dc.date2005
dc.dateNOV
dc.date2014-11-15T15:49:19Z
dc.date2015-11-26T17:20:37Z
dc.date2014-11-15T15:49:19Z
dc.date2015-11-26T17:20:37Z
dc.date.accessioned2018-03-29T00:08:13Z
dc.date.available2018-03-29T00:08:13Z
dc.identifierOral Diseases. Blackwell Publishing, v. 11, n. 6, n. 365, n. 369, 2005.
dc.identifier1354-523X
dc.identifierWOS:000232998700005
dc.identifier10.1111/j.1601-0825.2005.01130.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69649
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69649
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69649
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283178
dc.descriptionBACKGROUND: Oral avascular bone necrosis is an important adverse effect of chemotherapy and biphosphate therapy. OBJECTIVE: To report our experience in oral avascular bone necrosis in cancer patients assigned to undergo chemotherapy. PATIENTS AND METHODS: Fourteen patients presenting oral avascular bone necrosis were selected from the clinical files of five Stomatological Clinics in Brazil. Clinical data as well as treatment and prognosis information were obtained from all 14 patients. RESULTS: Twelve patients (86%) were submitted to biphosphonate therapy. The most important symptom was pain, present in all cases, and the mandible was the most common involved site. Most patients (79%) had their conditions managed by antibiotic therapy and surgical debridation; however complete response was achieved in only three cases (21%). CONCLUSION: Avascular bone necrosis is a serious oral side-effect of cancer chemotherapy, particularly in patients using biphosphonates, and antibiotic therapy and surgical debridation were not able to promote complete response in most cases.
dc.description11
dc.description6
dc.description365
dc.description369
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationOral Diseases
dc.relationOral Dis.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectchemotherapy
dc.subjectmouth
dc.subjectoral
dc.subjectbone
dc.subjectbiphosphonates
dc.subjectavascular bone necrosis
dc.subjectCancer-patients
dc.subjectRisk-factors
dc.subjectJaws
dc.subjectBisphosphonates
dc.subjectOsteonecrosis
dc.subjectLeukemia
dc.titleOral avascular bone necrosis associated with chemotherapy and biphosphonate therapy
dc.typeArtículos de revistas


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