Artículos de revistas
Influence of liposomal local anesthetics on platelet aggregation in vitro
Registro en:
Journal Of Liposome Research. Marcel Dekker Inc, v. 14, n. 41671, n. 51, n. 59, 2004.
0898-2104
WOS:000223984700004
10.1081/LPR-120039697
Autor
Pinto, LMA
Pereira, R
de Paula, E
de Nucci, G
Santana, MHA
Donato, JL
Institución
Resumen
We assessed the effect of local anesthetics (LA) from different families such as esters (benzocaine), linear aminoamides (lidocaine) and cyclic aminoamides (bupivacaine) on the platelet aggregation induced by ADP. Liposomal formulations of the three LA, prepared with egg phosphatidylcholine: cholesterol a-tocopherol, were also tested. The three LA were able to inhibit platelet aggregation induced by ADP, in the following order: bupivacaine > lidocaine > benzocaine. After encapsulation into liposomes the inhibitory effect increased for all anesthetics studied, showing that aggregation tests could be used to assess the toxicity of new drug formulations. 14 41671 51 59