Identification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population

dc.creatorAbdeen, H
dc.creatorMcErlean, C
dc.creatorMoraes, ME
dc.creatorRomero, M
dc.creatorMarques, SB
dc.creatorGoncales, AC
dc.creatorGuariento, EG
dc.creatorMiddleton, D
dc.date2007
dc.dateMAR
dc.date2014-11-14T21:11:55Z
dc.date2015-11-26T17:16:58Z
dc.date2014-11-14T21:11:55Z
dc.date2015-11-26T17:16:58Z
dc.date.accessioned2018-03-29T00:05:07Z
dc.date.available2018-03-29T00:05:07Z
dc.identifierTissue Antigens. Blackwell Publishing, v. 69, n. 3, n. 273, n. 276, 2007.
dc.identifier0001-2815
dc.identifierWOS:000245041000012
dc.identifier10.1111/j.1399-0039.2006.00788.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69184
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69184
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69184
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1282401
dc.descriptionTwo novel alleles, human leukocyte antigen (HLA)-B*3569, -B*4450 and a confirmatory sequence of HLA-A*2631 were identified during a routine typing for the Brazilian Bone Marrow Donor Registry. Sequence analysis of coding exons 2 and 3 revealed a single nucleotide substitution in HLA-B*3569 and two single nucleotide substitutions in HLA-B*4450, compared with closely related alleles. At the protein level, these substitutions result in a change of a single amino acid residue in each of HLA-B*3569 and -B*4450 at positions 74 (Arg > Pro) and 80 (Thr > Ile), respectively. These variations are located in the highly polymorphic region at the end of the alpha(1) domain of the HLA molecule. It appears that HLA-B*3569 arose from the analogous HLA-B*3510 through a point mutation. However, HLA-B*4450 may have arisen from HLA-B*440301 and -B*4425 by gene conversion.
dc.description69
dc.description3
dc.description273
dc.description276
dc.languageen
dc.publisherBlackwell Publishing
dc.publisherOxford
dc.publisherInglaterra
dc.relationTissue Antigens
dc.relationTissue Antigens
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectHLA-B*3569
dc.subjectHLA-B*4450
dc.subjectHLA-A*2631
dc.subjectnew allele
dc.subjectsequencing
dc.subjectPcr-ssop
dc.subjectSystem
dc.titleIdentification of two novel alleles HLA-B*3569 and -B*4450 and confirmation of HLA-A*2631 in the Brazilian population
dc.typeArtículos de revistas


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