Artículos de revistas
Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity
Registro en:
Journal Of Natural Products. Amer Chemical Soc, v. 67, n. 1, n. 42, n. 45, 2004.
0163-3864
WOS:000188364400009
10.1021/np0302697
Autor
da Silva, AA
Albuquerque, S
Silva, MLAE
Eberlin, MN
Tomazela, DM
Bastos, JK
Institución
Resumen
The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC50 value of 2.2 muM and lysis of 94% of the parasites at 32 muM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive. 67 1 42 45