Artículos de revistas
;Protective effect of collagen derivates on the ulcerative lesions caused by oral administration of ethanol
Registro en:
Journal Of Medicinal Food. Mary Ann Liebert Inc, v. 10, n. 1, n. 154, n. 158, 2007.
1096-620X
WOS:000246276100021
10.1089/jmf.2006.262
Autor
Castro, GA
Sgarbieri, VC
Carvalho, JE
Tinti, SV
Possenti, A
Institución
Resumen
The protective effect of beef and pig collagen hydrolysates and their fractions were tested as anti-ulcerogenic agents in rats (weighing 250-350 g) against ulcerative lesions caused by ethanol. Beef and pig collagen hydrolysates were fractionated by ultrafiltration into different molecular weight fractions. The protocol employed a negative and a positive control and a single dose of the experimental samples given by intragastric intubation. The beef collagen did not present a dose-response correlation in the ethanol model, whereas pig collagen showed a logarithmic dose-response relationship. Beef collagen hydrolysate decreased the ulcerative lesion index of 55% versus a 61% decrease for pig collagen hydrolysate at the same dosage (750 mg/ kg of body weight). No significant differences were found (P > .05) between the hydrolysates and their fractions. o TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015. 10 1 154 158