Human leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt

dc.creatorFavaro, PMB
dc.creatorMedina, SD
dc.creatorTraina, F
dc.creatorBasseres, DS
dc.creatorCosta, FF
dc.creatorSaad, STO
dc.date2003
dc.date41944
dc.date2014-11-14T10:03:34Z
dc.date2015-11-26T17:14:23Z
dc.date2014-11-14T10:03:34Z
dc.date2015-11-26T17:14:23Z
dc.date.accessioned2018-03-29T00:02:43Z
dc.date.available2018-03-29T00:02:43Z
dc.identifierBiochemical And Biophysical Research Communications. Academic Press Inc Elsevier Science, v. 311, n. 2, n. 365, n. 371, 2003.
dc.identifier0006-291X
dc.identifierWOS:000186584100019
dc.identifier10.1016/j.bbrc.2003.10.012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68912
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/68912
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68912
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281801
dc.descriptionThe very large family of Formin proteins is involved in processes such as morphogenesis, embryonic differentiation, cell polarity, and cytokinesis. A novel human gene from the Formin family, denominated human leukocyte formin gene, was cloned. The cDNA of the gene was determined to be 3959 bp long with an open reading frame of 3302 bp and computational analysis located this gene on chromosome 17, suggesting that it is composed of 27 exons. Northern blot analysis revealed a restricted expression of mRNA in the thymus, spleen, and peripheral blood leukocytes in normal human tissues. Western blot analysis demonstrated that the protein encoded by this gene is overexpressed in lymphoid malignancies; cancer cell lines and peripheral blood leukocyte from chronic lymphocytic leukemia (CLL) patients. Furthermore, the human leukocyte formin protein was observed to associate with Akt, a critical survival regulator in many different cell types. (C) 2003 Elsevier Inc. All rights reserved.
dc.description311
dc.description2
dc.description365
dc.description371
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationBiochemical And Biophysical Research Communications
dc.relationBiochem. Biophys. Res. Commun.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectformin
dc.subjecthuman leukocyte formin
dc.subjectlymphoid malignancies
dc.subjectPKB/Akt
dc.subjectChronic Lymphocytic-leukemia
dc.subjectPten
dc.subjectIdentification
dc.subjectStimulation
dc.subjectNucleation
dc.subjectSequence
dc.subjectProfilin
dc.subjectSurvival
dc.subjectPathway
dc.subjectDomains
dc.titleHuman leukocyte formin: a novel protein expressed in lymphoid malignancies and associated with Akt
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución