Artículos de revistas
MMP-2 and MMP-9 localization and activity in the female prostate during estrous cycle
Registro en:
General And Comparative Endocrinology. Academic Press Inc Elsevier Science, v. 173, n. 3, n. 419, n. 427, 2011.
0016-6480
WOS:000294978300007
10.1016/j.ygcen.2011.06.017
Autor
Santos, FCA
Rochel-Maia, SS
Fochi, RA
Justulin, LA
Santos, SAA
Vilamaior, PSL
Felisbino, SL
Goes, RM
Taboga, SR
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) The gerbil female prostate undergoes morphological and physiological changes resulting from hormonal fluctuations that occur during the reproductive cycle. These repetitive cycles of glandular growth and regression are followed by an extensive reconstruction and remodeling of prostate stroma throughout the reproductive life of the female gerbil. The objective of this study was to evaluate the effect that the hormonal fluctuations of the reproductive cycle have on the stromal remodeling and the expression and activity of matrix metalloproteinases MMP-2 and-gin the adult female gerbil prostate. For this, serological, ultrastructural, immunohistochemical and biochemical methods were employed. The results showed that the major stromal alteration coincide with the peak of estradiol, which occurs in estrus, and with the peak of progesterone, occurring during diestrus II. MMP-2 and -9 presented a similar pattern of expression and activity during estrous cycle. The estrus was the phase of greater expression and activity of MMP-2 and -9. On the other hand, in DI and DII, the tissue expression and activity of MMP-2 and -9 was very weak. These results are important since they suggest the involvement of estradiol and progesterone in regulating the expression and activity of MMP-2 and -9 in adult gerbil female prostate. (C) 2011 Elsevier Inc. All rights reserved. 173 3 419 427 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [06/06952-0, 06/06985-5, 06/06876-1] CNPq [301111/05-7, 300163/2008-8]