The effect of an immunosuppressive therapy and its withdrawal on bone healing around titanium implants. A histometric study in rabbits

dc.creatorDuarte, PM
dc.creatorNogueira, GR
dc.creatorSallum, EA
dc.creatorde Toledo, S
dc.creatorSallum, AW
dc.creatorNociti, FH
dc.date2001
dc.dateOCT
dc.date2014-11-13T17:52:01Z
dc.date2015-11-26T17:10:49Z
dc.date2014-11-13T17:52:01Z
dc.date2015-11-26T17:10:49Z
dc.date.accessioned2018-03-28T23:59:21Z
dc.date.available2018-03-28T23:59:21Z
dc.identifierJournal Of Periodontology. Amer Acad Periodontology, v. 72, n. 10, n. 1391, n. 1397, 2001.
dc.identifier0022-3492
dc.identifierWOS:000171841700012
dc.identifier10.1902/jop.2001.72.10.1391
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75011
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75011
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280953
dc.descriptionBackground: Immunosuppressive agents have been recognized as a factor affecting bone metabolism. We investigated the consequences of the administration and withdrawal of cyclosporin A/nifedipine on bone around titanium implants to observe whether these changes occur and if they are reversible. Methods: Twenty-eight New Zealand rabbits were included in the study. Following anesthesia, the tibiae surface was exposed, and 2 screw-shaped implants 7.0 mm in length and 3.75 mm in diameter were placed bilaterally. The animals were randomly assigned to 1 of 4 experimental groups and received daily subcutaneous injections for 14 days: groups A and C were injected with vehicle while groups B and D received cyclosporin A (10 mg/kg) plus nifedipine (0.5 mg/kg). Groups A and B were sacrificed 14 days and groups C and D 42 days postoperatively. The degree of bone contact with the implant surface and the bone area within the limits of the threads of the implant were measured. Results: Intergroup analysis revealed no significant difference (P >0.05) in the degree of bone contact with the implant surface between the control and test groups on days 14 and 42. In contrast, the treated animals demonstrated a significant (P <0.05) decrease in the bone area within the limits of the threads of the implant in both periods. Conclusions: The data of the present study suggest that the use of cyclosporin A/nifedipine may influence bone healing around titanium implants. This observation may have important clinical implications.
dc.description72
dc.description10
dc.description1391
dc.description1397
dc.languageen
dc.publisherAmer Acad Periodontology
dc.publisherChicago
dc.publisherEUA
dc.relationJournal Of Periodontology
dc.relationJ. Periodont.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjecttitanium
dc.subjectosseointegration
dc.subjectcyclosporin A/adverse effects
dc.subjectnifedipine/adverse effects
dc.subjectanimal studies
dc.subjectalveolar bone/anatomy and histology
dc.subjectdental implants/adverse effects
dc.subjectInduced Gingival Hyperplasia
dc.subjectCalcium-channel Blockers
dc.subjectLow-dose Cyclosporine
dc.subjectCardiac Transplantation
dc.subjectMineral Metabolism
dc.subjectDouble-blind
dc.subjectIn-vitro
dc.subjectRat
dc.subjectResorption
dc.subjectCells
dc.titleThe effect of an immunosuppressive therapy and its withdrawal on bone healing around titanium implants. A histometric study in rabbits
dc.typeArtículos de revistas


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