Artículos de revistas
Quantitative Spot-Test Analysis of Metformin in Pharmaceutical Preparations Using Ultraviolet-Visible Diffuse Reflectance Spectroscopy
Registro en:
Analytical Sciences. Japan Soc Analytical Chemistry, v. 26, n. 1, n. 121, n. 124, 2010.
0910-6340
WOS:000273653500020
Autor
Tubino, M
Bianchessi, LF
Vila, MMDC
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) A quantitative spot-test for the determination of metformin in pharmaceutical preparations using diffuse UV-visible reflectance is reported. The procedure is quite simple, involving in the formation of a metformin-nickel(II) complex on a glass filter membrane with a later measurement of the reflectance in the spectrophotometer using an integration sphere. The analytical results obtained with commercial products were statistically compared with those resulting from a method recommended by JP and by USP, where complete agreement was observed. The average RSD is 2.5% and the detection (0.009 mol L(-1)) and the quantitation (0.03 cool L(-1)) limits are quite adequate for pharmaceutical analysis. 26 1 121 124 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)