Artículos de revistas
Leucotrichoic acid, a novel sesquiterpene from Sinningia leucotricha (Gesneriaceae)
Registro en:
Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 54, n. 35, n. 4735, n. 4737, 2013.
0040-4039
WOS:000323020400033
10.1016/j.tetlet.2013.06.108
Autor
Verdan, MH
Unemoto, LK
Faria, RT
Salvador, MJ
de Sa, EL
Barison, A
Stefanello, MEA
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Chemical investigation of Sinningia leucotricha (Gesneriaceae) resulted in the isolation of leucotrichoic acid, a sesquiterpene with a novel triquinane skeleton, and the known triterpenes hederagenin and 23-hydroxyursolic acid. The chemical structures of all compounds were elucidated through spectroscopic analysis (NMR and MS). The conformational stability of the new compound was analyzed by density theory functional methods. A possible biogenesis for the new compound is proposed. Leucotrichoic acid was inactive against a panel of human cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved. 54 35 4735 4737 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) CNPq [462392/2011-5]