Fiber Type Composition of the Sternomastoid and Diaphragm Muscles of Dystrophin-Deficient mdx Mice

dc.creatorGuido, AN
dc.creatorCampos, GER
dc.creatorNeto, HS
dc.creatorMarques, MJ
dc.creatorMinatel, E
dc.date2010
dc.dateOCT
dc.date2014-11-19T12:04:05Z
dc.date2015-11-26T17:05:46Z
dc.date2014-11-19T12:04:05Z
dc.date2015-11-26T17:05:46Z
dc.date.accessioned2018-03-28T23:54:08Z
dc.date.available2018-03-28T23:54:08Z
dc.identifierAnatomical Record-advances In Integrative Anatomy And Evolutionary Biology. Wiley-liss, v. 293, n. 10, n. 1722, n. 1728, 2010.
dc.identifier1932-8486
dc.identifierWOS:000283272600010
dc.identifier10.1002/ar.21224
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66907
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66907
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66907
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279667
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe muscle fiber phenotype is mainly determined by motoneuron innervation and changes in neuromuscular interaction alter the muscle fiber type. In dystrophin-deficient mdx mice, changes in the molecular assembly of the neuromuscular junction and in nerve terminal sprouting occur in the sternomastoid (STN) muscle during early stages of the disease. In this study, we were interested to see whether early changes in neuromuscular assembly are correlated with alterations in fiber type in dystrophic STN at 2 months of age. A predominance of hybrid fast myo-fibers (about 52% type IIDB) was observed in control (C57B1/10) STN. In mdx muscle, the lack of dystrophin did not change this profile (about 54% hybrid type IIDB). Pure fast type HD fibers predominated in normal and dystrophic diaphragm (DIA; about 39% in control and 30% in mdx muscle) and a population of slow Type I fibers was also present (about 10% in control and 13% in mdx muscle). In conclusion, early changes in neuromuscular assembly do not affect the fiber type composition of dystrophic STN. In contrast to the pure fast fibers of the more affected DIA, the hybrid phenotype of the STN may permit dynamic adaptations during progression of the disease. Anat Rec, 293:1722-1728, 2010. (C) 2010 Wiley-Liss, Inc.
dc.description293
dc.description10
dc.description1722
dc.description1728
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [04/15526-9, 07/50189-1, 08/58491-1, 08/50731-3]
dc.descriptionCNPq [302006/09-5, 301386/07-2]
dc.languageen
dc.publisherWiley-liss
dc.publisherHoboken
dc.publisherEUA
dc.relationAnatomical Record-advances In Integrative Anatomy And Evolutionary Biology
dc.relationAnat. Rec.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectdiaphragm
dc.subjectfiber type
dc.subjectmdx mouse
dc.subjectsternomastoid muscle
dc.subjectDuchenne Muscular-dystrophy
dc.subjectDeveloping Neuromuscular-junction
dc.subjectSkeletal-muscle
dc.subjectEnd-plates
dc.subjectNerve-terminals
dc.subjectPotential Role
dc.subjectMouse Model
dc.subjectIn-vivo
dc.subjectCalcium
dc.subjectExercise
dc.titleFiber Type Composition of the Sternomastoid and Diaphragm Muscles of Dystrophin-Deficient mdx Mice
dc.typeArtículos de revistas


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