Anesthetic efficacy of liposomal prilocaine in maxillary infiltration anesthesia

dc.creatorZago, PMW
dc.creatorBaroni, DB
dc.creatorGroppo, FC
dc.creatorde Paula, E
dc.creatorRanali, J
dc.creatorVolpato, MC
dc.date2011
dc.dateMAR
dc.date2014-08-01T18:20:33Z
dc.date2015-11-26T17:05:41Z
dc.date2014-08-01T18:20:33Z
dc.date2015-11-26T17:05:41Z
dc.date.accessioned2018-03-28T23:54:02Z
dc.date.available2018-03-28T23:54:02Z
dc.identifierJournal Of Liposome Research. Informa Healthcare, v. 21, n. 1, n. 81, n. 87, 2011.
dc.identifier0898-2104
dc.identifier1532-2394
dc.identifierWOS:000287089600010
dc.identifier10.3109/08982101003754393
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77422
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77422
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279648
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAnimal studies have shown that liposome encapsulation increases prilocaine anesthetic efficacy. This randomized, blind, crossover, three-period study evaluated the anesthetic efficacy of liposome-encapsulated 3% prilocaine, compared to 3% plain prilocaine and 3% prilocaine with 0.03IU/mL felypressin, after a 1.8-mL infiltration in the buccal sulcus of the maxillary right canine, in 32 volunteers. Anesthesia success, onset, and duration of pulpal and gingival anesthesia in the lateral incisor, and canine and first premolar were evaluated. Injection pain was assessed by a visual analog scale (VAS). Results were submitted to Kruskal-Wallis (onset and duration of pulpal anesthesia), Tukey (VAS), Friedman (duration of gingival anesthesia), and log-rank and McNemar tests (anesthesia success) (a = 5%). Liposomal prilocaine did not differ from plain prilocaine (P > 0.05), but presented lower anesthesia success and duration for canine, premolar, and gingival anesthesia (P < 0.05) than prilocaine with felypressin. Liposomal prilocaine did not differ from the other formulations concerning onset and anesthesia success for the lateral incisor (p > 0.05); plain prilocaine presented lower success rates and slower onset of anesthesia for this tooth, in comparison to prilocaine with felypressin (P < 0.05). No differences were observed among the formulations in relation to duration of anesthesia for lateral incisor, VAS scores, and onset of gingival and pulpal anesthesia for the canine and premolar (P > 0.05). In conclusion, liposomal prilocaine presents similar anesthetic efficacy in relation to plain prilocaine and lower efficacy, in comparison to prilocaine with felypressin in maxillary infiltration. Prilocaine does not seem to benefit from liposomal encapsulation.
dc.description21
dc.description1
dc.description81
dc.description87
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [06/00121-9]
dc.descriptionCNPq [131843/2008-7]
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Liposome Research
dc.relationJ. Liposome Res.
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectPulpal anesthesia
dc.subjectliposome
dc.subjectlocal anesthetics
dc.subjectdental anesthesia
dc.subjectLocal Toxicity
dc.subjectPain Syndrome
dc.subjectRopivacaine
dc.subjectBupivacaine
dc.subjectMepivacaine
dc.subjectFormulation
dc.subjectLidocaine
dc.subjectAnalgesia
dc.subjectEpinephrine
dc.subjectManagement
dc.titleAnesthetic efficacy of liposomal prilocaine in maxillary infiltration anesthesia
dc.typeArtículos de revistas


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