Artículos de revistas
Synthesis, spectroscopic characterization, DFT studies, and antibacterial and antitumor activities of a novel water soluble Pd(II) complex with L-alliin
Registro en:
Journal Of Molecular Structure. Elsevier Science Bv, v. 1035, n. 421, n. 426, 2013.
0022-2860
WOS:000315315500056
10.1016/j.molstruc.2012.11.065
Autor
Abbehausen, C
Sucena, SF
Lancellotti, M
Heinrich, TA
Abrao, EP
Costa-Neto, CM
Formiga, ALB
Corbi, PP
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) A new water soluble Pd(II) complex with L-alliin (S-allyl-L-cysteine sulfoxide) was obtained and characterized by a set of chemical and spectroscopic measurements. Elemental and mass spectrometric data are consistent with the formula [Pd(C6H10NO3S)(2)]. The H-1 and C-13 nuclear magnetic resonance (NMR) data, [H-1-N-15] two dimensional (2D) NMR and infrared spectroscopic measurements indicate coordination of the ligand to Pd(II) through N and O atoms. DFT studies showed that the trans isomer is the most stable and preferred geometry for the complex. The complex is soluble in water and dimethylsulfoxide. An anti-biogram assay revealed that the complex possess antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains in the range 125-500 mu g mL(-1). Antitumor assays revealed that the complex presents cytotoxic activity over HeLa cells with an estimated IC50 of 20 mu mol L-1. (c) 2012 Elsevier B.V. All rights reserved. 1035 421 426 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPESP [Proc. 2012/08230-2]