Co-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3

dc.creatorSyrjanen, K
dc.creatorShabalova, I
dc.creatorNaud, P
dc.creatorDerchain, S
dc.creatorSarian, L
dc.creatorKozachenko, V
dc.creatorZakharchenko, S
dc.creatorRoteli-Martins, C
dc.creatorNerovjna, R
dc.creatorLongatto-Filho, A
dc.creatorKljukina, L
dc.creatorTatti, S
dc.creatorBranovskaja, M
dc.creatorBranca, M
dc.creatorGrunjberga, V
dc.creatorErzen, M
dc.creatorJuschenko, A
dc.creatorHammes, LS
dc.creatorCosta, S
dc.creatorPodistov, J
dc.creatorSyrjanen, S
dc.date2011
dc.dateMAY
dc.date2014-08-01T18:26:00Z
dc.date2015-11-26T17:05:17Z
dc.date2014-08-01T18:26:00Z
dc.date2015-11-26T17:05:17Z
dc.date.accessioned2018-03-28T23:53:39Z
dc.date.available2018-03-28T23:53:39Z
dc.identifierInternational Journal Of Std & Aids. Royal Soc Medicine Press Ltd, v. 22, n. 5, n. 263, n. 272, 2011.
dc.identifier0956-4624
dc.identifierWOS:000291567500005
dc.identifier10.1258/ijsa.2009.009280
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78851
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78851
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279548
dc.descriptionIn addition to oncogenic 'high-risk' human papillomaviruses (HR-HPV), several co-factors are needed in cervical carcinogenesis, but it is poorly understood whether these HPV co-factors associated with incident cervical intraepithelial neoplasia (CIN) grade 1 are different from those required for progression to CIN2 and CIN3. To gain further insights into the true biological differences between CIN1, CIN2 and CIN3, we assessed HPV co-factors increasing the risk of incident CIN1, CIN2 and CIN3. Data from the New Independent States of the Former Soviet Union (NIS) Cohort (n = 3187) and the Latin American Screening (LAMS) Study (n = 12,114) were combined, and co-factors associated with progression to CIN1, CIN2 and CIN3 were analysed using multinomial logistic regression models with all covariates recorded at baseline. HR-HPV-positive women (n = 1105) represented a subcohort of all 1865 women prospectively followed up in both studies. Altogether, 90(4.8%), 39 (2.1%) and 14 (1.4%) cases progressed to CIN1, CIN2 and CIN3, respectively. Baseline HR-HPV was the single most powerful predictor of incident CIN1, CIN2 and CIN3. When controlled for residual HPV confounding by analysing HR-HPV-positive women only, the risk profiles of incident CIN1, CIN2 and CIN3 were unique. Completely different HPV co-factors were associated with progression to CIN1, CIN2 and CIN3 in univariate and multivariate analyses, irrespective of whether non-progression, CIN1 or CIN2 was used as the reference outcome. HPV co-factors associated with progression to CIN1, CIN2 and CIN3 display unique profiles, implicating genuine biological differences between the three CIN grades, which prompts us to re-visit the concept of combining CIN2 with CIN3 or CIN1.
dc.description22
dc.description5
dc.description263
dc.description272
dc.descriptionEuropean Commission [ERB IC15-CT98-0321, ICA4-CT-2001-10013]
dc.descriptionEuropean Commission [ERB IC15-CT98-0321, ICA4-CT-2001-10013]
dc.languageen
dc.publisherRoyal Soc Medicine Press Ltd
dc.publisherLondon
dc.publisherInglaterra
dc.relationInternational Journal Of Std & Aids
dc.relationInt. J. STD AIDS
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectCIN
dc.subjectHPV
dc.subjectco-factors
dc.subjectprogression
dc.subjectmultinomial regression
dc.subjectprospective follow-up
dc.subjectNIS Cohort
dc.subjectLAMS Study
dc.subjectCervical Intraepithelial Neoplasia
dc.subjectLow-resource Settings
dc.subjectFormer Soviet-union
dc.subjectHpv Infections
dc.subjectLatin-america
dc.subjectScreening Tools
dc.subjectIndependent States
dc.subjectVisual Inspection
dc.subjectNatural-history
dc.subjectBethesda System
dc.titleCo-factors of high-risk human papillomavirus infections display unique profiles in incident CIN1, CIN2 and CIN3
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución