Artículos de revistas
Type 2 diabetes mellitus-an autoimmune disease?
Registro en:
Nature Reviews Endocrinology. Nature Publishing Group, v. 9, n. 12, n. 750, n. 755, 2013.
1759-5029
1759-5037
WOS:000327364000009
10.1038/nrendo.2013.131
Autor
Velloso, LA
Eizirik, DL
Cnop, M
Institución
Resumen
Inflammation-induced inhibition of the insulin signalling pathway can lead to insulin resistance and contribute to the development of type 2 diabetes mellitus (T2DM). Obesity and insulin resistance are associated with a chronic but subclinical inflammatory process that impairs insulin action in most tissues and could also hamper pancreatic 13-cell function. The involvement of monocytic cells and the profiles of the chemokines and cytokines induced by this inflammation suggest an innate immune response. However, emerging data indicate that elements of the adaptive immune system could also be involved. As activation of an adaptive response requires antigen specificity, some researchers have hypothesized that T2DM evolves from an innate immune response to an autoimmune condition. In this Perspectives article, we present the arguments for and against this hypothesis and discuss which mechanisms could be involved in a putative switch from innate immunity to autoimmunity. 9 12 750 755 Fundagfio de Amparo 8 Pesquisa do Estado de Sfio Paulo (Brazil) Communaute Frangaise de Belgique Actions de Recherche Concertees European Union