Renal kinetics of Bothrops alternatus (Urutu) snake venom in rats

dc.creatorMello, SM
dc.creatorLinardi, A
dc.creatorRenno, AL
dc.creatorTarsitano, CAB
dc.creatorPereira, EM
dc.creatorHyslop, S
dc.date2010
dc.dateFEB-MAR
dc.date2014-11-19T04:26:15Z
dc.date2015-11-26T17:02:01Z
dc.date2014-11-19T04:26:15Z
dc.date2015-11-26T17:02:01Z
dc.date.accessioned2018-03-28T23:50:00Z
dc.date.available2018-03-28T23:50:00Z
dc.identifierToxicon. Pergamon-elsevier Science Ltd, v. 55, n. 41700, n. 470, n. 480, 2010.
dc.identifier0041-0101
dc.identifierWOS:000274579100037
dc.identifier10.1016/j.toxicon.2009.09.018
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70906
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70906
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70906
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278827
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe renal kinetics of Bothrops alternatus venom (0.8 mg/kg, i.v.) was studied in conscious male Wistar rats. Blood, urine and renal tissue samples were collected at various intervals after envenoming. Venom was quantified by ELISA in serum, renal tissue and urine. Urine volume was measured and the urine assayed for urobilinogen, glucose, bilirubin, ketones, urine specific gravity, occult blood, pH, protein, nitrite and leucocytes. Circulating venom showed biexponential kinetics, with no venom being detected after 7 days post-venom. Venom was detected in renal tissue 30 min post-venom but decreased progressively thereafter, in parallel with serum venom concentrations. Immunohistochemistry detected venom in glomeruli, proximal and distal tubules, and vascular and perivascular tissue. Venom was detected in urine 3, 6 and 24 h post-venom. Oliguria occurred 3 h to 7 days post-venom, urine acidification occurred 3-6 h post-venom, urine specific gravity increased in the first 3 h and proteinuria was also greatest in this period. Creatinine clearance decreased progressively until 24-48 h post-venom, then returned to normal. Glucose, ketones, leucocytes and occult blood were detected mainly during the first 6 h post-venom. These results indicate reversible alterations in renal function, with renal elimination of the venom. (C) 2009 Elsevier Ltd. All rights reserved.
dc.description55
dc.description41700
dc.description470
dc.description480
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationToxicon
dc.relationToxicon
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAcute renal failure
dc.subjectBothrops
dc.subjectELISA
dc.subjectElimination
dc.subjectEnvenoming
dc.subjectImmunohistochemistry
dc.subjectNephrotoxicity
dc.subjectVenom pharmacokinetics
dc.subjectLinked-immunosorbent-assay
dc.subjectExperimentally Envenomed Rabbits
dc.subjectInsularis Venom
dc.subjectJararaca Venom
dc.subjectPhospholipase A(2)
dc.subjectCrotalus-durissus
dc.subjectViper Venom
dc.subjectMyotoxin-i
dc.subjectPharmacokinetics
dc.subjectPurification
dc.titleRenal kinetics of Bothrops alternatus (Urutu) snake venom in rats
dc.typeArtículos de revistas


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