Antinociceptive and anti-inflammatory effects of novel dietary protein hydrolysate produced from whey by proteases of Cynara cardunculus

dc.creatorTavares, TG
dc.creatorSpindola, H
dc.creatorLongato, G
dc.creatorPintado, ME
dc.creatorCarvalho, JE
dc.creatorMalcata, FX
dc.date2013
dc.dateOCT
dc.date2014-08-01T18:22:11Z
dc.date2015-11-26T16:59:05Z
dc.date2014-08-01T18:22:11Z
dc.date2015-11-26T16:59:05Z
dc.date.accessioned2018-03-28T23:46:46Z
dc.date.available2018-03-28T23:46:46Z
dc.identifierInternational Dairy Journal. Elsevier Sci Ltd, v. 32, n. 2, n. 156, n. 162, 2013.
dc.identifier0958-6946
dc.identifierWOS:000321744300015
dc.identifier10.1016/j.idairyj.2013.05.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77847
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77847
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1278103
dc.descriptionAntinociceptive and anti-inflammatory effects of a peptide concentrate mix (PepC) obtained from whey protein, via hydrolysis with cardosins from Cynara cardunculus, was tested in vivo. The antinociceptive effect was assessed using writhing, hot-plate and formalin tests in mice, and the anti-inflammatory effect using the paw oedema test. PepC at 300 mg kg(-1) bw conveyed a significant result in the writhing test when co-administered with 1 and 3 mg kg(-1) bw indomethacin, similar to administration of higher doses of indomethacin alone. Conversely, no statistically significant differences were observed in the paw oedema test when the same PepC concentration was co-administered with dexamethasone at 3, 10 and 30 mg kg(-1) bw. PepC at 1000 mg kg(-1) bw did not cause any remarkable outcome in the hot-plate test. PepC appears to possess anti-inflammatory and peripheral antinociceptive activities, so it may be a candidate for nutraceutical ingredient. (C) 2013 Elsevier Ltd. All rights reserved.
dc.description32
dc.description2
dc.description156
dc.description162
dc.descriptionFCT e via project NEW PROTECTION [PTDC/AGR-ALI/117658/2010]
dc.description[SFRH/BD/31604/2006]
dc.descriptionFCT e via project NEW PROTECTION [PTDC/AGR-ALI/117658/2010]
dc.description[SFRH/BD/31604/2006]
dc.languageen
dc.publisherElsevier Sci Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationInternational Dairy Journal
dc.relationInt. Dairy J.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectMilk-derived Lactoferrin
dc.subjectMouse Paw Edema
dc.subjectRat Spinal-cord
dc.subjectFormalin Test
dc.subjectNitric-oxide
dc.subjectAlpha-lactalbumin
dc.subjectInflammatory Pain
dc.subjectAnalgesic Action
dc.subjectOpioid Receptor
dc.subjectHind Paw
dc.titleAntinociceptive and anti-inflammatory effects of novel dietary protein hydrolysate produced from whey by proteases of Cynara cardunculus
dc.typeArtículos de revistas


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