IMMUNOHISTOCHEMICAL STUDY OF THE INFLAMMATORY INFILTRATE IN VILLITIS OF UNKNOWN ETIOLOGY - A QUALITATIVE AND QUANTITATIVE-ANALYSIS

dc.creatorALTEMANI, AM
dc.date1992
dc.dateAPR
dc.date2014-07-30T18:05:56Z
dc.date2015-11-26T16:53:21Z
dc.date2014-07-30T18:05:56Z
dc.date2015-11-26T16:53:21Z
dc.date.accessioned2018-03-28T23:40:27Z
dc.date.available2018-03-28T23:40:27Z
dc.identifierPathology Research And Practice. Gustav Fischer Verlag, v. 188, n. 3, n. 303, n. 309, 1992.
dc.identifier0344-0338
dc.identifierWOS:A1992HQ37500006
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69962
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69962
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276557
dc.descriptionVillitis is characterized by an inflammatory infiltrate within the substance of the chorionic villi. Quantitative and qualitative analyses of the mononuclear infiltrate in areas of villitis were performed in placentas with villitis of unknown etiology (VUE). We used a panel of monoclonal antibodies and immunoperoxidase technique in paraffin sections from 17 placentas with VUE and 8 without VUE. Macrophages followed by T lymphocytes were the predominant inflammatory cells in areas of villitis in virtually all cases. B lymphocytes were not observed and monocytes were present usually in small number in 58 per cent of the cases. Mononuclear cells which expressed HLA-DR antigens were found in 75 per cent of the cases. In areas of villitis with trophoblastic necrosis, we found monocytes and some T lymphocytes adhered to them. These cells apparently had migrated from the maternal circulation. We suggest that in areas of villitis with destruction of the trophoblast and its basal membrane the inflammatory infiltrate might have a mixture of fetal and maternal cells. The maternal monocytes and T lymphocytes might be attracted to these sites of trophoblastic necrosis and activated due to exposure to fetal MHC antigens of the villous stroma.
dc.description188
dc.description3
dc.description303
dc.description309
dc.languageen
dc.publisherGustav Fischer Verlag
dc.publisherJena
dc.publisherAlemanha
dc.relationPathology Research And Practice
dc.relationPathol. Res. Pract.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectPLACENTA
dc.subjectVILLITIS
dc.subjectMACROPHAGES
dc.subjectLYMPHOCYTES-T
dc.subjectGestational-age Infants
dc.subjectHuman-placenta
dc.subjectExpression
dc.subjectAntibodies
dc.subjectPregnancy
dc.subjectAntigen
dc.subjectTissues
dc.subjectLesion
dc.titleIMMUNOHISTOCHEMICAL STUDY OF THE INFLAMMATORY INFILTRATE IN VILLITIS OF UNKNOWN ETIOLOGY - A QUALITATIVE AND QUANTITATIVE-ANALYSIS
dc.typeArtículos de revistas


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