Immunohistochemical expression of Skp2 protein in oral nevi and melanoma

dc.creatorBenevenuto-de-Andrade, BA
dc.creatorLeon, JE
dc.creatorCarlos, R
dc.creatorDelgado-Azanero, W
dc.creatorMosqueda-Taylor, A
dc.creatorPaes-de-Almeida, O
dc.date2013
dc.dateMAY
dc.date2014-07-30T18:05:55Z
dc.date2015-11-26T16:53:21Z
dc.date2014-07-30T18:05:55Z
dc.date2015-11-26T16:53:21Z
dc.date.accessioned2018-03-28T23:40:26Z
dc.date.available2018-03-28T23:40:26Z
dc.identifierMedicina Oral Patologia Oral Y Cirugia Bucal. Medicina Oral S L, v. 18, n. 3, n. E388, n. E391, 2013.
dc.identifier1698-6946
dc.identifierWOS:000322566000003
dc.identifier10.4317/medoral.18781
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69957
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69957
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276554
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionObjective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions.
dc.description18
dc.description3
dc.descriptionE388
dc.descriptionE391
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCAPES [CAPES/PDSE 8661-11-1]
dc.languageen
dc.publisherMedicina Oral S L
dc.publisherValencia
dc.publisherEspanha
dc.relationMedicina Oral Patologia Oral Y Cirugia Bucal
dc.relationMed. Oral Patol. Oral Cir. Bucal
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectOral melanoma
dc.subjectoral nevi
dc.subjectSkp2
dc.subjectcell cycle
dc.subjectimmunohistochemistry
dc.subjectF-box Protein
dc.subjectInverse Relationship
dc.subjectMalignant-melanoma
dc.subjectUbiquitin Ligase
dc.subjectS-phase
dc.subjectP27(kip1)
dc.subjectDegradation
dc.subjectCarcinomas
dc.subjectP45(skp2)
dc.subjectProstate
dc.titleImmunohistochemical expression of Skp2 protein in oral nevi and melanoma
dc.typeArtículos de revistas


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