Artículos de revistas
Energy deposition in small-scale targets of liquid water using the very low energy electromagnetic physics processes of the Geant4 toolkit
Registro en:
Nuclear Instruments & Methods In Physics Research Section B-beam Interactions With Materials And Atoms. Elsevier Science Bv, v. 306, n. 158, n. 164, 2013.
0168-583X
WOS:000321085900034
10.1016/j.nimb.2012.12.054
Autor
Incerti, S
Champion, C
Tran, HN
Karamitros, M
Bernal, M
Francis, Z
Ivanchenko, V
Mantero, A
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) In the perspective of building an open source simulation platform dedicated to the modelling of early biological molecular damages due to ionising radiation at the DNA scale, the general-purpose Geant4 Monte Carlo simulation toolkit has been recently extended with specific very low energy electromagnetic physics processes for liquid water medium. These processes - also called "Geant4-DNA" processes - simulate the physical interactions induced by electrons, hydrogen and helium atoms of different charge states. The present work reports on the energy deposit distributions obtained for incident electrons, protons and alpha particles in nanometre-size volumes comparable to those present in the genetic material of mammalian cells. The frequency distributions of the energy deposition obtained for three typical geometries of nanometre-size cylindrical targets placed in a spherical phantom are found to be in reasonable agreement with prior works. Furthermore, we present a combination of the Geant4-DNA processes with a simplified geometrical model of a cellular nucleus allowing the evaluation of energy deposits in volumes of biological interest. (C) 2013 Elsevier B.V. All rights reserved. 306 158 164 French Agence Nationale de la Recherche [ANR-09-BLAN-0135-01] European Space Agency [AO6041-22712/09/NL/AT] RFBR [09-02-91065] CNRS [PICS-4865] FAEPEX fund UNICAMP Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Programme de Cooperation ECOS-Sud [A09E04] Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) French Agence Nationale de la Recherche [ANR-09-BLAN-0135-01] European Space Agency [AO6041-22712/09/NL/AT] RFBR [09-02-91065] CNRS [PICS-4865] FAPESP [FAPESP 2011/51594-2] Programme de Cooperation ECOS-Sud [A09E04]