Sensitivity to beta-adrenoceptor agonists of adipocytes from rats treated with an aqueous extract of Croton cajucara Benth

dc.creatorGrassi-Kassisse, DM
dc.creatorWolf-Nunes, V
dc.creatorMiotto, AM
dc.creatorFarias-Silva, E
dc.creatorBrito, ARMS
dc.creatorNunes, DS
dc.creatorSpadari-Bratfisch, RC
dc.date2003
dc.dateFEB
dc.date2014-11-18T06:07:15Z
dc.date2015-11-26T16:51:59Z
dc.date2014-11-18T06:07:15Z
dc.date2015-11-26T16:51:59Z
dc.date.accessioned2018-03-28T23:38:50Z
dc.date.available2018-03-28T23:38:50Z
dc.identifierJournal Of Pharmacy And Pharmacology. Royal Pharmaceutical Soc Great Britain, v. 55, n. 2, n. 253, n. 257, 2003.
dc.identifier0022-3573
dc.identifierWOS:000181617300014
dc.identifier10.1211/002235702595
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/71475
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/71475
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/71475
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1276144
dc.descriptionAqueous extracts of Croton cajucara bark are used in folk medicine to treat hepatic and gastrointestinal disorders and as a coadjuvant in weight-loss programs. We examined the effect of treating rats for 15 days with a 5% aqueous extract of C. cajucara on body weight and food intake. The epididymal adipose pads were removed and the lipolytic responses of isolated adipocytes to isoprenaline, noradrenaline (norepinephrine), BRL37344 and adrenaline (epinephrine) were analysed in the absence or presence of metoprolol or ICI118,551. Treated rats had a significantly lower weight gain than control rats, with no difference in food and liquid intake, epididymal fat-pad weight or basal glycerol release. The sensitivity of the lipolytic response to isoprenaline and adrenaline was significantly higher in adipocytes from treated rats. The sensitivity to noradrenaline or BRL37344 was unaltered. Metoprolol shifted the dose-response curves to noradrenaline to the right in adipocytes from control and treated rats; the dose-response curve to isoprenaline in adipocytes from control rats was also shifted to the right. In adipocytes from treated rats, the dose-response curve to isoprenaline was unaltered by metoprolol but was shifted to the right by ICI118,551, a beta(2)-adrenoceptor antagonist. We conclude that in adipocytes from treated rats there is an increase in the lipolytic response to non-selective agonists (isoprenaline and adrenaline) mediated by beta(2)-adrenoceptors, with no alteration in the responses mediated by beta(1)-adrenoceptors (noradrenaline) or beta(3)-adrenoceptors (BRL37344). This effect could increase the role of adrenaline as an endogenous stimulator of lipolysis.
dc.description55
dc.description2
dc.description253
dc.description257
dc.languageen
dc.publisherRoyal Pharmaceutical Soc Great Britain
dc.publisherLondon
dc.publisherInglaterra
dc.relationJournal Of Pharmacy And Pharmacology
dc.relationJ. Pharm. Pharmacol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectFat-cell Function
dc.subjectWhite Adipocytes
dc.subjectEssential Oil
dc.subjectDehydrocrotonin
dc.titleSensitivity to beta-adrenoceptor agonists of adipocytes from rats treated with an aqueous extract of Croton cajucara Benth
dc.typeArtículos de revistas


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